Semaphorin 3C is a novel adipokine linked to extracellular matrix composition
نویسندگان
چکیده
منابع مشابه
WISP1 is a novel adipokine linked to inflammation in obesity.
WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the secreted extracellular matrix-associated proteins of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway. Growing evidence links the WNT signaling pathway to the regulation of adipogenesis and low-grade inflammation in obesity. We aimed to validate WISP1 as a novel adipokine. Huma...
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Introduction The extracellular matrix is a network of proteins and carbohydrates that supports and surrounds the cells in connective tissues. In addition to their structural-mechanical functions ECM molecules regulate diverse cellular functions, and play a significant role in several physiological and pathological processes, such as embryonic development, inflammation and wound healing, hemosta...
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Extracellular matrix (ECM) composition has an important role in determining airway structure. We postulated that ECM lung composition of chronic obstructive pulmonary disease (COPD) patients differs from that observed in smoking and nonsmoking subjects without airflow obstruction. We determined the fractional areas of elastic fibres, type-I, -III and -IV collagen, versican, decorin, biglycan, l...
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Background. The lumen of novel threadlike structures (NTSs) is enclosed by a single layer of endothelial cells surrounded by extracellular matrix (ECM). We hypothesized that collagen may be a component of the ECM associated with lymphatic NTSs. Methods. Six female New Zealand white rabbits were anesthetized, and the NTS structures within lymphatic vessels were identified by contrast-enhanced st...
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In the developing cortex, axons and dendrites extend progressively in response to environmental cues attracting or repelling growing processes. Recent evidence suggests the existence of a functional link between guidance molecules and metalloproteinases. Here, we analyzed the putative functional interaction of matrix metalloproteinases (MMPs) with guidance cues of the semaphorin family during g...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2013
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-013-2931-z